Heredity plus milieu determines fate
Each character is treated as the product of two inputs: a temperament inherited from the ancestral lesion (Tante Dide's nervous instability, Antoine Macquart's alcoholism) and the pressures of a specific social environment. The same bloodline yields a minister, a financier, a painter, a prostitute or a murderer depending on which milieu the inherited disposition meets, so outcome is read as inheritance times circumstance rather than as free choice.
