Charlie Gordon's surgically raised, then lost, intelligence
Charlie Gordon is a 32-year-old bakery worker with an IQ of 68. He undergoes an experimental brain operation, first tested on a mouse named Algernon, and his IQ climbs to about 185, and he discovers the procedure's fatal flaw himself (the 'Algernon-Gordon Effect'). He then records his own decline back toward his original state, ending with a request that someone put flowers on Algernon's grave.
